藥物交互作用
Amobarbital + Avatrombopag
嚴重程度: 中度
Amobarbital and Avatrombopag: moderate interaction.
最後更新
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摘要
Amobarbital may lower avatrombopag exposure by inducing metabolizing enzymes, potentially reducing platelet count response. Moderate to strong dual inducers have been shown to reduce avatrombopag levels.
用白話說明這項交互作用的意義
Amobarbital and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Avatrombopag belongs to Miscellaneous.
為什麼會發生
Induction of CYP3A4 and CYP2C9 metabolism of avatrombopag by the barbiturate.
處置方式
Monitor platelet counts and adjust avatrombopag dose per labeling when a dual inducer is started or stopped. Prefer a non-inducing sedative if possible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amobarbital 的其他交互作用
Avatrombopag 的其他交互作用
常見問題
Can I take Amobarbital with Avatrombopag?
MediHelp rates the interaction as moderate. Amobarbital and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may lower avatrombopag exposure by inducing metabolizing enzymes, potentially reducing platelet count response. Moderate to strong dual inducers have been shown to reduce avatrombopag levels.
How serious is the interaction between Amobarbital and Avatrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and adjust avatrombopag dose per labeling when a dual inducer is started or stopped. Prefer a non-inducing sedative if possible.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
