藥物交互作用
Amiodarone + Avatrombopag
嚴重程度: 中度
Amiodarone and Avatrombopag: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amiodarone inhibits CYP3A4 moderately and may raise avatrombopag exposure. Higher exposure can increase the platelet count response and the risk of thrombotic events.
用白話說明這項交互作用的意義
Amiodarone and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Avatrombopag belongs to Miscellaneous.
為什麼會發生
Inhibition of CYP3A4 (and possibly CYP2C9) metabolism of avatrombopag by amiodarone.
處置方式
Follow avatrombopag labeling for a reduced starting dose with moderate dual CYP2C9/3A4 inhibitors in ITP. Monitor platelet counts and adjust the dose accordingly.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amiodarone 的其他交互作用
Avatrombopag 的其他交互作用
常見問題
Can I take Amiodarone with Avatrombopag?
MediHelp rates the interaction as moderate. Amiodarone and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 moderately and may raise avatrombopag exposure. Higher exposure can increase the platelet count response and the risk of thrombotic events.
How serious is the interaction between Amiodarone and Avatrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow avatrombopag labeling for a reduced starting dose with moderate dual CYP2C9/3A4 inhibitors in ITP. Monitor platelet counts and adjust the dose accordingly.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
