藥物交互作用
Avatrombopag + Bosentan
嚴重程度: 中度
Avatrombopag and Bosentan: moderate interaction.
最後更新
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摘要
Bosentan may reduce avatrombopag exposure through CYP3A4 and possibly CYP2C9 induction, potentially diminishing the platelet response.
用白話說明這項交互作用的意義
Avatrombopag and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Bosentan belongs to Miscellaneous.
為什麼會發生
Bosentan induces CYP3A4 (and CYP2C9), accelerating avatrombopag clearance.
處置方式
Monitor platelet counts and increase avatrombopag dose as recommended in labeling when used with inducers.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bosentan 的其他交互作用
Avatrombopag 的其他交互作用
常見問題
Can I take Avatrombopag with Bosentan?
MediHelp rates the interaction as moderate. Avatrombopag and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce avatrombopag exposure through CYP3A4 and possibly CYP2C9 induction, potentially diminishing the platelet response.
How serious is the interaction between Avatrombopag and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and increase avatrombopag dose as recommended in labeling when used with inducers.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
