藥物交互作用
Axicabtagene ciloleucel + Sulphasalazine
嚴重程度: 中度
Axicabtagene ciloleucel and Sulphasalazine: moderate interaction.
最後更新
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摘要
Sulfasalazine has modest immunomodulatory activity and can cause cytopenias. CAR-T recipients have profound immune compromise and infection risk, and concurrent immunosuppressants may impair CAR-T expansion or add to toxicity.
用白話說明這項交互作用的意義
Axicabtagene ciloleucel and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axicabtagene ciloleucel belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
為什麼會發生
Additive immunosuppression and possible myelosuppression, which may blunt CAR-T cell activity.
處置方式
Review the need for sulfasalazine around lymphodepletion and infusion, and hold it if possible. Monitor blood counts and infection.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Sulphasalazine 的其他交互作用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Axicabtagene ciloleucel with Sulphasalazine?
MediHelp rates the interaction as moderate. Axicabtagene ciloleucel and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine has modest immunomodulatory activity and can cause cytopenias. CAR-T recipients have profound immune compromise and infection risk, and concurrent immunosuppressants may impair CAR-T expansion or add to toxicity.
How serious is the interaction between Axicabtagene ciloleucel and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for sulfasalazine around lymphodepletion and infusion, and hold it if possible. Monitor blood counts and infection.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
