藥物交互作用
Bcg intravesical live + Rifaximin
嚴重程度: 中度
Bcg intravesical live and Rifaximin: moderate interaction.
最後更新
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摘要
Intravesical BCG depends on viable mycobacteria to induce a local immune response against bladder cancer. Antibiotics with antimycobacterial activity may reduce BCG viability and therapeutic effect. Rifaximin is minimally absorbed and its systemic exposure is low, so the risk is lower than with systemic antituberculous agents.
用白話說明這項交互作用的意義
Bcg intravesical live and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibacterial activity may reduce viability of the live BCG organisms, though rifaximin has little systemic exposure.
處置方式
Where possible, defer BCG instillations until the antibiotic course is finished. If rifaximin must continue, monitor response to BCG therapy.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Rifaximin 的其他交互作用
常見問題
Can I take Bcg intravesical live with Rifaximin?
MediHelp rates the interaction as moderate. Bcg intravesical live and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravesical BCG depends on viable mycobacteria to induce a local immune response against bladder cancer. Antibiotics with antimycobacterial activity may reduce BCG viability and therapeutic effect. Rifaximin is minimally absorbed and its systemic exposure is low, so the risk is lower than with systemic antituberculous agents.
How serious is the interaction between Bcg intravesical live and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, defer BCG instillations until the antibiotic course is finished. If rifaximin must continue, monitor response to BCG therapy.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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