藥物交互作用
Amiodarone + Rifaximin
嚴重程度: 中度
Amiodarone and Rifaximin: moderate interaction.
最後更新
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摘要
Amiodarone inhibits P-glycoprotein and may increase systemic rifaximin absorption. Rifaximin's systemic exposure is normally very low, so the effect is of limited importance except in severe liver disease.
用白話說明這項交互作用的意義
Amiodarone and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Rifaximin belongs to Anti Bacterial.
為什麼會發生
P-glycoprotein inhibition by amiodarone reduces intestinal efflux of rifaximin.
處置方式
Rifaximin labeling advises caution with P-gp inhibitors in hepatic impairment; monitor for rifaximin adverse effects and avoid unnecessary dose escalation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Rifaximin 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Rifaximin?
MediHelp rates the interaction as moderate. Amiodarone and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and may increase systemic rifaximin absorption. Rifaximin's systemic exposure is normally very low, so the effect is of limited importance except in severe liver disease.
How serious is the interaction between Amiodarone and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Rifaximin labeling advises caution with P-gp inhibitors in hepatic impairment; monitor for rifaximin adverse effects and avoid unnecessary dose escalation.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Bcg intravesical live. The full list is on the Rifaximin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
