藥物交互作用
Cyclosporine + Rifaximin
嚴重程度: 中度
Cyclosporine and Rifaximin: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
用白話說明這項交互作用的意義
Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Cyclosporine inhibition of P-glycoprotein markedly increases rifaximin absorption.
處置方式
Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Rifaximin 的其他交互作用
常見問題
Can I take Cyclosporine with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
How serious is the interaction between Cyclosporine and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
