藥物交互作用
Cyclosporin + Rifaximin
嚴重程度: 中度
Cyclosporin and Rifaximin: moderate interaction.
最後更新
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摘要
Cyclosporine markedly increases systemic absorption of rifaximin, which is normally minimally absorbed. In patients with intact gut barrier this has been very large, and the consequences of such exposure are not well defined.
用白話說明這項交互作用的意義
Cyclosporin and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Rifaximin belongs to Anti Bacterial.
為什麼會發生
Cyclosporine inhibits P-glycoprotein, which limits rifaximin absorption, greatly increasing systemic rifaximin levels.
處置方式
Avoid combining where possible, particularly in patients with severe hepatic impairment. If used, monitor for adverse effects of rifaximin and for changes in cyclosporine levels.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cyclosporin 的其他交互作用
Rifaximin 的其他交互作用
常見問題
Can I take Cyclosporin with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporin and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine markedly increases systemic absorption of rifaximin, which is normally minimally absorbed. In patients with intact gut barrier this has been very large, and the consequences of such exposure are not well defined.
How serious is the interaction between Cyclosporin and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, particularly in patients with severe hepatic impairment. If used, monitor for adverse effects of rifaximin and for changes in cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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