藥物交互作用
Cholera vaccine + Rifaximin
嚴重程度: 嚴重
Cholera vaccine and Rifaximin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
The oral live attenuated cholera vaccine needs viable bacteria to colonize and stimulate immunity. Antibiotics active against V. cholerae could lower the immune response. Rifaximin has activity against many enteric bacteria and acts locally in the gut, where the vaccine strain must establish.
用白話說明這項交互作用的意義
Cholera vaccine and Rifaximin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Luminal antibacterial activity in the gut can reduce viability and colonization of the live attenuated vaccine strain.
處置方式
Do not give the vaccine to patients who have recently had antibiotics; follow the labeled interval after the antibiotic course (14 days is stated in labeling). Delay the vaccine rather than the antibiotic when treatment is needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rifaximin 的其他交互作用
常見問題
Can I take Cholera vaccine with Rifaximin?
MediHelp rates the interaction as major. Cholera vaccine and Rifaximin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live attenuated cholera vaccine needs viable bacteria to colonize and stimulate immunity. Antibiotics active against V. cholerae could lower the immune response. Rifaximin has activity against many enteric bacteria and acts locally in the gut, where the vaccine strain must establish.
How serious is the interaction between Cholera vaccine and Rifaximin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have recently had antibiotics; follow the labeled interval after the antibiotic course (14 days is stated in labeling). Delay the vaccine rather than the antibiotic when treatment is needed.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Microbiota, Amiodarone, Bcg intravesical live. The full list is on the Rifaximin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
