藥品參考
Rifaximin
Rifaximin is a medicine in the class anti bacterial. It is used for hepatic encephalopathy.
- 藥物類別: Anti Bacterial
- 用途: hepatic encephalopathy
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重點資訊
- 藥物類別
- Anti Bacterial
- 常見劑型
- 錠劑
- 常見規格
- 200 mg, 550 mg
- 已知交互作用
- 55 (嚴重: 2 · 中度: 15 · 輕微: 38)
- 商品名
- 26
- 國家與市場
- 4
用途
作用方式
Antimicrobial action is a result of binding to the beta-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of transcription, Hepatic encephalopathy: Inhibits growth of enteric ammonia-producing bacteria to indirectly reduce serum ammonia level
成人常用劑量（仿單摘要）
Traveler's Diarrhea: 200 mg PO q8hr for 3 days
懷孕與哺乳
- 懷孕
- Unknown Very little is absorbed from the gut, but in animals it caused birth defects (eye, face, heart, spine), some at doses near human exposure. No human data. EU label: not recommended in pregnancy as a precaution.
- 哺乳
- Unknown Not known if it passes into milk; poorly absorbed, so unlikely to reach the infant. LactMed: no published experience, so another drug may be preferred, especially with a newborn or preterm infant. EU label: decide whether to stop breastfeeding or the drug.
已通報的副作用
- Headache
- Nausea
- Constipation
- Abdominal pain
- Flatulence
- Rectal tenesmus
禁忌症
- Hypersensitivity to rifamycin antibiotics
哪些人需要特別留意
- Possibility of pseudomembranous colitis
- Monitor patients with severe hepatic impairment for increased systemic exposure
- Coadministration of cyclosporine with rifaximin resulted in 83-fold and 124-fold increases in rifaximin mean Cmax and AUC in healthy subjects
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (55)
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Dronedarone + Rifaximin Moderate
- Itraconazole + Rifaximin Moderate
- Ketoconazole + Rifaximin Moderate
- Lasmiditan + Rifaximin Moderate
常見問題
What is Rifaximin used for?
Rifaximin is a medicine in the class anti bacterial. It is used for Hepatic encephalopathy, Irritable bowel syndrome, Traveler's diarrhea.
What side effects have been reported with Rifaximin?
Headache, Nausea, Constipation, Abdominal pain, Flatulence, Rectal tenesmus.
Can Rifaximin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Very little is absorbed from the gut, but in animals it caused birth defects (eye, face, heart, spine), some at doses near human exposure. No human data. EU label: not recommended in pregnancy as a precaution. Breastfeeding: Unknown. Not known if it passes into milk; poorly absorbed, so unlikely to reach the infant. LactMed: no published experience, so another drug may be preferred, especially with a newborn or preterm infant. EU label: decide whether to stop breastfeeding or the drug.
What does Rifaximin interact with?
MediHelp lists 55 known interactions for Rifaximin. Major: 2 · Moderate: 15 · Minor: 38. The most serious include Cholera vaccine, Microbiota, Amiodarone.
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