藥物交互作用
Carbamazepine + Etravirine
嚴重程度: 嚴重
Carbamazepine and Etravirine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Carbamazepine induces CYP3A4 and CYP2C enzymes and can substantially lower etravirine concentrations, risking virologic failure and NNRTI resistance. Coadministration is not recommended.
用白話說明這項交互作用的意義
Carbamazepine and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Etravirine belongs to Anti Virals.
為什麼會發生
Carbamazepine induces CYP3A4 and CYP2C, increasing etravirine metabolism.
處置方式
Avoid and choose a non-inducing anticonvulsant or different antiretroviral. Monitor HIV RNA if unavoidable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Etravirine 的其他交互作用
常見問題
Can I take Carbamazepine with Etravirine?
MediHelp rates the interaction as major. Carbamazepine and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine induces CYP3A4 and CYP2C enzymes and can substantially lower etravirine concentrations, risking virologic failure and NNRTI resistance. Coadministration is not recommended.
How serious is the interaction between Carbamazepine and Etravirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and choose a non-inducing anticonvulsant or different antiretroviral. Monitor HIV RNA if unavoidable.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
