藥物交互作用
Efavirenz + Etravirine
嚴重程度: 禁忌併用
Efavirenz and Etravirine: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Efavirenz substantially lowers etravirine concentrations, which may cause loss of virologic control. Combining two NNRTIs offers no benefit and is not recommended.
用白話說明這項交互作用的意義
Efavirenz and Etravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Etravirine belongs to Anti Virals.
為什麼會發生
Efavirenz induces CYP3A4 and CYP2C19, increasing etravirine metabolism.
處置方式
Do not coadminister. Use a single NNRTI within a regimen suited to the resistance profile.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Efavirenz 的其他交互作用
Etravirine 的其他交互作用
常見問題
Can I take Efavirenz with Etravirine?
MediHelp rates the interaction as contraindicated. Efavirenz and Etravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz substantially lowers etravirine concentrations, which may cause loss of virologic control. Combining two NNRTIs offers no benefit and is not recommended.
How serious is the interaction between Efavirenz and Etravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use a single NNRTI within a regimen suited to the resistance profile.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
