藥物交互作用
Cefepime + Streptomycin
嚴重程度: 中度
Cefepime and Streptomycin: moderate interaction.
最後更新
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摘要
Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
用白話說明這項交互作用的意義
Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
為什麼會發生
Additive renal tubular stress; the aminoglycoside accumulates in proximal tubular and inner ear cells and any reduction in renal function raises its exposure.
處置方式
Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefepime 的其他交互作用
Streptomycin 的其他交互作用
常見問題
Can I take Cefepime with Streptomycin?
MediHelp rates the interaction as moderate. Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
How serious is the interaction between Cefepime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
