藥物交互作用
Cefotaxime + Tobramycin
嚴重程度: 中度
Cefotaxime and Tobramycin: moderate interaction.
最後更新
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摘要
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with cefotaxime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
用白話說明這項交互作用的意義
Cefotaxime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotaxime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
為什麼會發生
Possible additive nephrotoxicity, with reduced renal function leading to higher aminoglycoside exposure and greater ototoxic potential.
處置方式
Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefotaxime 的其他交互作用
Tobramycin 的其他交互作用
常見問題
Can I take Cefotaxime with Tobramycin?
MediHelp rates the interaction as moderate. Cefotaxime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with cefotaxime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
How serious is the interaction between Cefotaxime and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
