藥物交互作用
Chlorothiazide + Ergocalciferol
嚴重程度: 中度
Chlorothiazide and Ergocalciferol: moderate interaction.
最後更新
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摘要
Thiazide diuretics reduce urinary calcium excretion, and vitamin D increases calcium absorption from the gut. Combined use can lead to hypercalcemia, especially with high vitamin D doses or underlying hyperparathyroidism or renal disease.
用白話說明這項交互作用的意義
Chlorothiazide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Ergocalciferol belongs to Musculoskeletal.
為什麼會發生
Thiazides increase renal tubular calcium reabsorption, adding to vitamin D-mediated increases in calcium absorption.
處置方式
Monitor serum calcium at baseline and periodically during therapy. Reduce the vitamin D dose or reconsider the thiazide if hypercalcemia occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ergocalciferol 的其他交互作用
Chlorothiazide 的其他交互作用
常見問題
Can I take Chlorothiazide with Ergocalciferol?
MediHelp rates the interaction as moderate. Chlorothiazide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and vitamin D increases calcium absorption from the gut. Combined use can lead to hypercalcemia, especially with high vitamin D doses or underlying hyperparathyroidism or renal disease.
How serious is the interaction between Chlorothiazide and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium at baseline and periodically during therapy. Reduce the vitamin D dose or reconsider the thiazide if hypercalcemia occurs.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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