藥物交互作用
Cholic acid + Glyburide
嚴重程度: 嚴重
Cholic acid and Glyburide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Glyburide inhibits the bile salt export pump and may impair biliary excretion of bile acids. In patients taking cholic acid, this may promote hepatic accumulation of bile salts and liver injury.
用白話說明這項交互作用的意義
Cholic acid and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholic acid belongs to Gastrointestinal Tract; Glyburide belongs to Endocrine.
為什麼會發生
Inhibition of the hepatic bile salt export pump (BSEP) by glyburide reduces bile acid efflux.
處置方式
Avoid the combination if possible and choose another antidiabetic agent. If it is necessary, monitor serum transaminases and bilirubin regularly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glyburide 的其他交互作用
Cholic acid 的其他交互作用
常見問題
Can I take Cholic acid with Glyburide?
MediHelp rates the interaction as major. Cholic acid and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide inhibits the bile salt export pump and may impair biliary excretion of bile acids. In patients taking cholic acid, this may promote hepatic accumulation of bile salts and liver injury.
How serious is the interaction between Cholic acid and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose another antidiabetic agent. If it is necessary, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Ciprofloxacin, Clarithromycin. The full list is on the Glyburide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
