藥物交互作用
Glyburide + Insulin degludec-liraglutide
嚴重程度: 嚴重
Glyburide and Insulin degludec-liraglutide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Combining a GLP-1 agonist and insulin with glyburide increases the risk of hypoglycemia, which can be severe and prolonged. Glyburide has a long duration of action and active metabolites.
用白話說明這項交互作用的意義
Glyburide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
為什麼會發生
Additive stimulation of insulin secretion and insulin effect, producing synergistic glucose lowering.
處置方式
Consider reducing the glyburide dose, or choosing a shorter-acting alternative, when this combination is started. Monitor glucose closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin degludec-liraglutide 的其他交互作用
Glyburide 的其他交互作用
常見問題
Can I take Glyburide with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Glyburide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a GLP-1 agonist and insulin with glyburide increases the risk of hypoglycemia, which can be severe and prolonged. Glyburide has a long duration of action and active metabolites.
How serious is the interaction between Glyburide and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose, or choosing a shorter-acting alternative, when this combination is started. Monitor glucose closely.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
