藥物交互作用
Clarithromycin + Glyburide
嚴重程度: 嚴重
Clarithromycin and Glyburide: major interaction.
最後更新
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摘要
Clarithromycin has been linked to severe hypoglycemia in patients taking glyburide, especially older adults and those with renal dysfunction. Clarithromycin may also increase glyburide exposure by inhibiting transport and metabolism.
用白話說明這項交互作用的意義
Clarithromycin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Glyburide belongs to Endocrine.
為什麼會發生
Clarithromycin may inhibit CYP3A4 and OATP/P-glycoprotein handling of glyburide, while also enhancing insulin secretion.
處置方式
Avoid the combination if possible or use azithromycin instead. If used together, monitor blood glucose frequently and reduce the glyburide dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Glyburide 的其他交互作用
常見問題
Can I take Clarithromycin with Glyburide?
MediHelp rates the interaction as major. Clarithromycin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin has been linked to severe hypoglycemia in patients taking glyburide, especially older adults and those with renal dysfunction. Clarithromycin may also increase glyburide exposure by inhibiting transport and metabolism.
How serious is the interaction between Clarithromycin and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or use azithromycin instead. If used together, monitor blood glucose frequently and reduce the glyburide dose.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
