藥物交互作用
Fluconazole + Glyburide
嚴重程度: 嚴重
Fluconazole and Glyburide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Fluconazole raises glyburide levels and prolongs its half-life, increasing the risk of significant hypoglycemia. Severe episodes have been reported with sulfonylureas and azole antifungals.
用白話說明這項交互作用的意義
Fluconazole and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glyburide belongs to Endocrine.
為什麼會發生
Fluconazole inhibits CYP2C9 (and CYP3A4), decreasing glyburide metabolism.
處置方式
Monitor blood glucose closely and lower the glyburide dose when starting fluconazole. Consider an alternative antidiabetic or antifungal if hypoglycemia occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluconazole 的其他交互作用
Glyburide 的其他交互作用
常見問題
Can I take Fluconazole with Glyburide?
MediHelp rates the interaction as major. Fluconazole and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises glyburide levels and prolongs its half-life, increasing the risk of significant hypoglycemia. Severe episodes have been reported with sulfonylureas and azole antifungals.
How serious is the interaction between Fluconazole and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and lower the glyburide dose when starting fluconazole. Consider an alternative antidiabetic or antifungal if hypoglycemia occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
