藥物交互作用
Cilostazol + Ticlopidine
嚴重程度: 嚴重
Cilostazol and Ticlopidine: major interaction.
最後更新
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摘要
Ticlopidine inhibits CYP2C19 and raises exposure to cilostazol's active metabolites, increasing risks such as headache, tachycardia and bleeding. Both drugs impair platelet function, adding to bleeding risk.
用白話說明這項交互作用的意義
Cilostazol and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilostazol belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
為什麼會發生
CYP2C19 inhibition reduces cilostazol metabolism, plus additive antiplatelet effects.
處置方式
Reduce the cilostazol dose to 50 mg twice daily per labeling when given with strong CYP2C19 inhibitors. Monitor for bleeding, palpitations and headache.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ticlopidine 的其他交互作用
Cilostazol 的其他交互作用
常見問題
Can I take Cilostazol with Ticlopidine?
MediHelp rates the interaction as major. Cilostazol and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits CYP2C19 and raises exposure to cilostazol's active metabolites, increasing risks such as headache, tachycardia and bleeding. Both drugs impair platelet function, adding to bleeding risk.
How serious is the interaction between Cilostazol and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cilostazol dose to 50 mg twice daily per labeling when given with strong CYP2C19 inhibitors. Monitor for bleeding, palpitations and headache.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
