藥物交互作用
Clomipramine + Liothyronine
嚴重程度: 中度
Clomipramine and Liothyronine: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Thyroid hormones can increase sensitivity to catecholamines and tricyclics may enhance this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly with excess thyroid hormone. Tricyclic effect may also be accelerated when thyroid hormone is used for augmentation.
用白話說明這項交互作用的意義
Clomipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Liothyronine belongs to Endocrine.
為什麼會發生
Thyroid hormone increases adrenergic receptor sensitivity, adding to tricyclic noradrenergic and cardiac effects.
處置方式
Monitor heart rate, rhythm and thyroid function, and watch for agitation or tremor. Keep thyroid replacement dose at the lowest effective level.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clomipramine 的其他交互作用
Liothyronine 的其他交互作用
常見問題
Can I take Clomipramine with Liothyronine?
MediHelp rates the interaction as moderate. Clomipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and tricyclics may enhance this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly with excess thyroid hormone. Tricyclic effect may also be accelerated when thyroid hormone is used for augmentation.
How serious is the interaction between Clomipramine and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and thyroid function, and watch for agitation or tremor. Keep thyroid replacement dose at the lowest effective level.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
