藥物交互作用
Amitriptyline + Liothyronine
嚴重程度: 中度
Amitriptyline and Liothyronine: moderate interaction.
最後更新
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摘要
Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
用白話說明這項交互作用的意義
Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Liothyronine belongs to Endocrine.
為什麼會發生
Increased adrenergic receptor sensitivity from thyroid hormone augments tricyclic cardiovascular and CNS effects.
處置方式
Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amitriptyline 的其他交互作用
Liothyronine 的其他交互作用
常見問題
Can I take Amitriptyline with Liothyronine?
MediHelp rates the interaction as moderate. Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
How serious is the interaction between Amitriptyline and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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