藥物交互作用
Cocaine + Phenylephrine
嚴重程度: 嚴重
Cocaine and Phenylephrine: major interaction.
最後更新
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摘要
Cocaine combined with phenylephrine can cause additive vasoconstriction and pressor effects, increasing the risk of severe hypertension, myocardial ischemia and arrhythmia.
用白話說明這項交互作用的意義
Cocaine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
為什麼會發生
Additive sympathomimetic effects: cocaine reuptake blockade plus alpha-1 agonism.
處置方式
Avoid additional vasoconstrictors where possible. If unavoidable, use the lowest dose with prolonged ECG and blood pressure monitoring.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cocaine 的其他交互作用
Phenylephrine 的其他交互作用
常見問題
Can I take Cocaine with Phenylephrine?
MediHelp rates the interaction as major. Cocaine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine combined with phenylephrine can cause additive vasoconstriction and pressor effects, increasing the risk of severe hypertension, myocardial ischemia and arrhythmia.
How serious is the interaction between Cocaine and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid additional vasoconstrictors where possible. If unavoidable, use the lowest dose with prolonged ECG and blood pressure monitoring.
What other medicines interact with Cocaine?
MediHelp also lists interactions of Cocaine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Cocaine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
