藥物交互作用
Dacomitinib + Flecainide
嚴重程度: 嚴重
Dacomitinib and Flecainide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Dacomitinib strongly inhibits CYP2D6, which is a main route of flecainide metabolism. Flecainide levels may therefore rise, increasing the risk of conduction abnormalities and proarrhythmia because it has a narrow therapeutic index.
用白話說明這項交互作用的意義
Dacomitinib and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Flecainide belongs to Cardiovascular.
為什麼會發生
Dacomitinib inhibits CYP2D6, reducing flecainide clearance.
處置方式
Avoid the combination where possible. If it cannot be avoided, monitor the ECG and flecainide plasma concentrations, and reduce the flecainide dose as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Flecainide 的其他交互作用
Dacomitinib 的其他交互作用
常見問題
Can I take Dacomitinib with Flecainide?
MediHelp rates the interaction as major. Dacomitinib and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, which is a main route of flecainide metabolism. Flecainide levels may therefore rise, increasing the risk of conduction abnormalities and proarrhythmia because it has a narrow therapeutic index.
How serious is the interaction between Dacomitinib and Flecainide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, monitor the ECG and flecainide plasma concentrations, and reduce the flecainide dose as needed.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
