藥物交互作用
Demeclocycline + Magnesium sulphate
嚴重程度: 中度
Demeclocycline and Magnesium sulphate: moderate interaction.
最後更新
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摘要
Oral magnesium binds demeclocycline in the gut to form poorly absorbed complexes. This can substantially reduce tetracycline levels and cause treatment failure. The interaction applies to oral magnesium, not intravenous administration.
用白話說明這項交互作用的意義
Demeclocycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Chelation of demeclocycline by magnesium cations in the gastrointestinal tract decreases absorption.
處置方式
Give demeclocycline at least 2 hours before or 4 to 6 hours after oral magnesium preparations. Alternatively use a non-chelating antibiotic or a non-magnesium laxative or antacid.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium sulphate 的其他交互作用
常見問題
Can I take Demeclocycline with Magnesium sulphate?
MediHelp rates the interaction as moderate. Demeclocycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium binds demeclocycline in the gut to form poorly absorbed complexes. This can substantially reduce tetracycline levels and cause treatment failure. The interaction applies to oral magnesium, not intravenous administration.
How serious is the interaction between Demeclocycline and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give demeclocycline at least 2 hours before or 4 to 6 hours after oral magnesium preparations. Alternatively use a non-chelating antibiotic or a non-magnesium laxative or antacid.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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