藥物交互作用
Amikacin + Magnesium sulphate
嚴重程度: 中度
Amikacin and Magnesium sulphate: moderate interaction.
最後更新
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摘要
Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
用白話說明這項交互作用的意義
Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
為什麼會發生
Aminoglycoside tubular toxicity increases renal magnesium loss, and both agents impair neuromuscular transmission, producing additive effects.
處置方式
Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium sulphate 的其他交互作用
Amikacin 的其他交互作用
常見問題
Can I take Amikacin with Magnesium sulphate?
MediHelp rates the interaction as moderate. Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
How serious is the interaction between Amikacin and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amphotericin b deoxycholate, Atracurium, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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