藥物交互作用
Atracurium + Magnesium sulphate
嚴重程度: 中度
Atracurium and Magnesium sulphate: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.
用白話說明這項交互作用的意義
Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Magnesium sulphate belongs to Cardiovascular.
為什麼會發生
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity at the neuromuscular junction, adding to competitive blockade.
處置方式
Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium sulphate 的其他交互作用
Atracurium 的其他交互作用
常見問題
Can I take Atracurium with Magnesium sulphate?
MediHelp rates the interaction as moderate. Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.
How serious is the interaction between Atracurium and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
