藥物交互作用
Domperidone + Polyethylene Glycol 3350
嚴重程度: 中度
Domperidone and Polyethylene Glycol 3350: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
用白話說明這項交互作用的意義
Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Pharmacodynamic and indirect: laxative-induced fluid and electrolyte loss lowers potassium and magnesium, which potentiates the QT-prolonging effect of domperidone. No pharmacokinetic interaction is expected.
處置方式
Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- Domperidone Summary of Product Characteristics - Special warnings and precautions (cardiovascular effects, electrolyte disturbances) — EMA SmPC
- Domperidone: risks of cardiac side effects - restricted indications, new contraindications, and reduced dose and duration of use — MHRA Drug Safety Update
Domperidone 的其他交互作用
常見問題
Can I take Domperidone with Polyethylene Glycol 3350?
MediHelp rates the interaction as moderate. Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
How serious is the interaction between Domperidone and Polyethylene Glycol 3350?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
