藥物交互作用
Domperidone + Pantoprazole
嚴重程度: 中度
Domperidone and Pantoprazole: moderate interaction.
最後更新 來源: US FDA label
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摘要
Prolonged pantoprazole use can cause hypomagnesaemia, and low magnesium or potassium increases susceptibility to QT prolongation and torsades de pointes with domperidone. This is an indirect, risk-factor-based interaction and is mainly relevant with long-term PPI use. Patients with cardiac disease, older patients and those taking diuretics are at higher risk.
用白話說明這項交互作用的意義
Domperidone and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Pantoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Pharmacodynamic: PPI-induced hypomagnesaemia, often with hypokalaemia, lowers the threshold for domperidone-related QTc prolongation.
處置方式
Use the lowest effective domperidone dose for the shortest time. Check serum magnesium and potassium, particularly if PPI therapy has lasted more than about 3 months or the patient takes diuretics or digoxin, and correct deficits.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- Motilium (domperidone) Summary of Product Characteristics — EMA SmPC
- Protonix (pantoprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
Domperidone 的其他交互作用
Pantoprazole 的其他交互作用
常見問題
Can I take Domperidone with Pantoprazole?
MediHelp rates the interaction as moderate. Domperidone and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged pantoprazole use can cause hypomagnesaemia, and low magnesium or potassium increases susceptibility to QT prolongation and torsades de pointes with domperidone. This is an indirect, risk-factor-based interaction and is mainly relevant with long-term PPI use. Patients with cardiac disease, older patients and those taking diuretics are at higher risk.
How serious is the interaction between Domperidone and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective domperidone dose for the shortest time. Check serum magnesium and potassium, particularly if PPI therapy has lasted more than about 3 months or the patient takes diuretics or digoxin, and correct deficits.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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