藥物交互作用
Domperidone + Rabeprazole
嚴重程度: 中度
Domperidone and Rabeprazole: moderate interaction.
最後更新 來源: US FDA label
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摘要
Prolonged rabeprazole therapy can cause hypomagnesemia, which together with low potassium raises the risk of QT prolongation and ventricular arrhythmia with domperidone. The effect is uncommon, typically follows months of PPI use, and matters most in older patients, those on diuretics or digoxin, and those with heart disease or other QT-prolonging drugs.
用白話說明這項交互作用的意義
Domperidone and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Rabeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Indirect pharmacodynamic: PPI-related hypomagnesemia reduces repolarisation reserve and potentiates the hERG-mediated QT prolongation of domperidone.
處置方式
Measure magnesium and potassium before starting domperidone in patients on long-term rabeprazole and correct any deficiency. Use the lowest effective domperidone dose for the shortest duration.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- AcipHex (rabeprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
- Domperidone - Summary of Product Characteristics: Cardiac effects and QT prolongation — EMA SmPC
- PRAC recommendation: Domperidone-containing medicines - restricted use (2014) — EMA
Domperidone 的其他交互作用
Rabeprazole 的其他交互作用
常見問題
Can I take Domperidone with Rabeprazole?
MediHelp rates the interaction as moderate. Domperidone and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged rabeprazole therapy can cause hypomagnesemia, which together with low potassium raises the risk of QT prolongation and ventricular arrhythmia with domperidone. The effect is uncommon, typically follows months of PPI use, and matters most in older patients, those on diuretics or digoxin, and those with heart disease or other QT-prolonging drugs.
How serious is the interaction between Domperidone and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure magnesium and potassium before starting domperidone in patients on long-term rabeprazole and correct any deficiency. Use the lowest effective domperidone dose for the shortest duration.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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