藥品參考
Domperidone
Domperidone is a medicine in the class gastrointestinal tract. It is used for dyspepsia.
- 藥物類別: Gastrointestinal Tract
- 用途: dyspepsia
最後更新 來源: Health Canada product monograph, UK SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Gastrointestinal Tract
- 常見劑型
- 錠劑, 栓劑, 口服懸液, 散劑包, 膠囊, 糖漿
- 常見規格
- 10 mg, 1 mg/ml, 60 mg
- 已知交互作用
- 8 (禁忌併用: 2 · 中度: 5 · 輕微: 1)
- 商品名
- 69
- 國家與市場
- 4
用途
作用方式
Domperidone is a dopamine antagonist with anti-emetic properties, Domperidone does not readily cross the blood-brain barrier. Domperidone promotes the release of prolactin from the pituitary.
成人常用劑量（仿單摘要）
One 10mg tablet up to three times per day with maximum dose of 30 mg per day.
懷孕與哺乳
- 懷孕
- Unknown Limited human data have not shown a rise in birth defects; high, maternally toxic doses harmed rat fetuses. UK label: use in pregnancy only when justified by the expected benefit. Better-studied antiemetics are preferred for pregnancy sickness.
- 哺乳
- Safe Very low milk levels (under 0.1% of the mother's dose) and no infant harm in published cases; it is used to boost milk supply. It carries a heart rhythm risk for the mother. UK label: decide between breastfeeding and the drug, as infant heart effects cannot be excluded.
已通報的副作用
- Headache
- Dry mouth
- Diarrhea
- Somnolence
禁忌症
- Hypersensitivity to domperidone or any formulation ingredient.
- Known prolongation of cardiac conduction intervals, particularly QT; significant electrolyte disturbances; underlying cardiac disease such as congestive heart failure.
- Moderate or severe liver impairment.
哪些人需要特別留意
- May be associated with serious ventricular arrhythmias or sudden cardiac death; risk may be higher in patients over 60 or at daily doses above 30 mg. Use the lowest dose for the shortest duration.
- Patients at higher risk of QT prolongation or arrhythmia should be considered for cardiac assessment before and during treatment.
- Moderate CYP3A4 inhibitors such as diltiazem, verapamil and some macrolides are not recommended with domperidone.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (8)
- Azithromycin + Domperidone Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dexlansoprazole + Domperidone Moderate
- Domperidone + Lansoprazole Moderate
- Domperidone + Pantoprazole Moderate
- Domperidone + Polyethylene Glycol 3350 Moderate
- Domperidone + Rabeprazole Moderate
- Domperidone + Omeprazole Minor
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Domperidone 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Domperidone used for?
Domperidone is a medicine in the class gastrointestinal tract. It is used for Dyspepsia, Heartburn, Nausea & vomiting.
What side effects have been reported with Domperidone?
Headache, Dry mouth, Diarrhea, Somnolence.
Can Domperidone be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data have not shown a rise in birth defects; high, maternally toxic doses harmed rat fetuses. UK label: use in pregnancy only when justified by the expected benefit. Better-studied antiemetics are preferred for pregnancy sickness. Breastfeeding: Safe. Very low milk levels (under 0.1% of the mother's dose) and no infant harm in published cases; it is used to boost milk supply. It carries a heart rhythm risk for the mother. UK label: decide between breastfeeding and the drug, as infant heart effects cannot be excluded.
What does Domperidone interact with?
MediHelp lists 8 known interactions for Domperidone. Contraindicated: 2 · Moderate: 5 · Minor: 1. The most serious include Azithromycin, Erythromycin, Dexlansoprazole.
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