藥物交互作用
Dexlansoprazole + Domperidone
嚴重程度: 中度
Dexlansoprazole and Domperidone: moderate interaction.
最後更新 來源: US FDA label
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摘要
Prolonged proton pump inhibitor use can cause hypomagnesemia and secondary hypokalemia or hypocalcemia, which increase vulnerability to QT prolongation and torsades de pointes. Domperidone has a dose-related QT-prolonging effect, so electrolyte depletion raises its arrhythmic risk. Risk is highest in older patients, those with cardiac disease and those taking other QT-prolonging drugs or diuretics.
用白話說明這項交互作用的意義
Dexlansoprazole and Domperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Domperidone belongs to Gastrointestinal Tract.
為什麼會發生
Pharmacodynamic: PPI-induced hypomagnesemia (and secondary hypokalemia) potentiates the QTc-prolonging effect of domperidone. No relevant pharmacokinetic interaction is expected.
處置方式
Use the lowest effective domperidone dose for the shortest time and correct magnesium, potassium and calcium before starting. Recheck magnesium periodically in patients on long-term PPI therapy, particularly if they also take diuretics or digoxin.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- Dexilant (dexlansoprazole) Prescribing Information - Warnings and Precautions: Hypomagnesemia — FDA Label
- Domperidone Summary of Product Characteristics — EMA SmPC
Domperidone 的其他交互作用
Dexlansoprazole 的其他交互作用
常見問題
Can I take Dexlansoprazole with Domperidone?
MediHelp rates the interaction as moderate. Dexlansoprazole and Domperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged proton pump inhibitor use can cause hypomagnesemia and secondary hypokalemia or hypocalcemia, which increase vulnerability to QT prolongation and torsades de pointes. Domperidone has a dose-related QT-prolonging effect, so electrolyte depletion raises its arrhythmic risk. Risk is highest in older patients, those with cardiac disease and those taking other QT-prolonging drugs or diuretics.
How serious is the interaction between Dexlansoprazole and Domperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective domperidone dose for the shortest time and correct magnesium, potassium and calcium before starting. Recheck magnesium periodically in patients on long-term PPI therapy, particularly if they also take diuretics or digoxin.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Lansoprazole. The full list is on the Domperidone page.
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