藥物交互作用
Fentanyl + Pyrilamine
嚴重程度: 中度
Fentanyl and Pyrilamine: moderate interaction.
最後更新
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摘要
Pyrilamine is a sedating first-generation antihistamine, and fentanyl is an opioid. Together they increase drowsiness and psychomotor impairment and may add to respiratory depression.
用白話說明這項交互作用的意義
Fentanyl and Pyrilamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Pyrilamine belongs to Respiratory.
為什麼會發生
Additive CNS depression through histamine H1 blockade and opioid receptor agonism.
處置方式
Avoid unnecessary use of sedating antihistamines with opioids, or use lower doses and monitor sedation. Advise against driving and alcohol.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Fentanyl 的其他交互作用
Pyrilamine 的其他交互作用
常見問題
Can I take Fentanyl with Pyrilamine?
MediHelp rates the interaction as moderate. Fentanyl and Pyrilamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrilamine is a sedating first-generation antihistamine, and fentanyl is an opioid. Together they increase drowsiness and psychomotor impairment and may add to respiratory depression.
How serious is the interaction between Fentanyl and Pyrilamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary use of sedating antihistamines with opioids, or use lower doses and monitor sedation. Advise against driving and alcohol.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
