藥物交互作用
Gefitinib + Rifampicin
嚴重程度: 嚴重
Gefitinib and Rifampicin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rifampicin markedly lowers gefitinib plasma concentrations through enzyme induction. Subtherapeutic exposure may lead to loss of tumour control.
用白話說明這項交互作用的意義
Gefitinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Rifampicin belongs to Anti Bacterial.
為什麼會發生
Induction of CYP3A4 by rifampicin increases the metabolic clearance of gefitinib.
處置方式
Avoid the combination if possible. If rifampicin is necessary, raise gefitinib to 500 mg daily as per labeling and return to 250 mg after the inducer has been stopped for about 7 days.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Gefitinib 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Gefitinib with Rifampicin?
MediHelp rates the interaction as major. Gefitinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly lowers gefitinib plasma concentrations through enzyme induction. Subtherapeutic exposure may lead to loss of tumour control.
How serious is the interaction between Gefitinib and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If rifampicin is necessary, raise gefitinib to 500 mg daily as per labeling and return to 250 mg after the inducer has been stopped for about 7 days.
What other medicines interact with Gefitinib?
MediHelp also lists interactions of Gefitinib with, for example, Apalutamide, Carbamazepine, Dexlansoprazole. The full list is on the Gefitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
