藥物交互作用
Glycerol phenylbutyrate + Hydrocortisone
嚴重程度: 中度
Glycerol phenylbutyrate and Hydrocortisone: moderate interaction.
最後更新
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摘要
Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.
用白話說明這項交互作用的意義
Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
為什麼會發生
Corticosteroid-induced protein breakdown increases nitrogen load and ammonia production, counteracting nitrogen scavenging.
處置方式
Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Hydrocortisone 的其他交互作用
Glycerol phenylbutyrate 的其他交互作用
常見問題
Can I take Glycerol phenylbutyrate with Hydrocortisone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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