藥物交互作用
Insulin degludec-liraglutide + Rosiglitazone
嚴重程度: 嚴重
Insulin degludec-liraglutide and Rosiglitazone: major interaction.
最後更新
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摘要
Rosiglitazone improves insulin sensitivity, and combining it with insulin and liraglutide adds to the glucose-lowering effect and the risk of hypoglycemia. Rosiglitazone with insulin also increases the risk of edema and heart failure.
用白話說明這項交互作用的意義
Insulin degludec-liraglutide and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-liraglutide belongs to Endocrine; Rosiglitazone belongs to Endocrine.
為什麼會發生
Additive glucose lowering from insulin sensitization combined with insulin and GLP-1 receptor agonism, with thiazolidinedione-related fluid retention.
處置方式
Avoid the combination where possible, particularly in patients with or at risk of heart failure. If used, monitor glucose, reduce the insulin dose as needed and watch for edema and weight gain.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin degludec-liraglutide 的其他交互作用
Rosiglitazone 的其他交互作用
常見問題
Can I take Insulin degludec-liraglutide with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity, and combining it with insulin and liraglutide adds to the glucose-lowering effect and the risk of hypoglycemia. Rosiglitazone with insulin also increases the risk of edema and heart failure.
How serious is the interaction between Insulin degludec-liraglutide and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in patients with or at risk of heart failure. If used, monitor glucose, reduce the insulin dose as needed and watch for edema and weight gain.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
