藥物交互作用
Isavuconazonium + Pimozide
嚴重程度: 禁忌併用
Isavuconazonium and Pimozide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Isavuconazole is a moderate CYP3A4 inhibitor, and pimozide is a CYP3A4 substrate with a narrow margin of safety. Higher pimozide levels can cause serious QT prolongation and ventricular arrhythmias, and other azoles are contraindicated with pimozide.
用白話說明這項交互作用的意義
Isavuconazonium and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Pimozide belongs to Central Nervous System.
為什麼會發生
CYP3A4 inhibition by isavuconazole raises pimozide concentrations, adding to its QT liability.
處置方式
Avoid concomitant use and choose a different antifungal or antipsychotic. If unavoidable, close ECG monitoring is required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pimozide 的其他交互作用
Isavuconazonium 的其他交互作用
常見問題
Can I take Isavuconazonium with Pimozide?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isavuconazole is a moderate CYP3A4 inhibitor, and pimozide is a CYP3A4 substrate with a narrow margin of safety. Higher pimozide levels can cause serious QT prolongation and ventricular arrhythmias, and other azoles are contraindicated with pimozide.
How serious is the interaction between Isavuconazonium and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a different antifungal or antipsychotic. If unavoidable, close ECG monitoring is required.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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