藥物交互作用
Ivabradine + Lopinavir
嚴重程度: 禁忌併用
Ivabradine and Lopinavir: contraindicated interaction.
最後更新
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摘要
Lopinavir is co-formulated with ritonavir, which strongly inhibits CYP3A4 and increases ivabradine levels. Excessive bradycardia and conduction disturbances may follow.
用白話說明這項交互作用的意義
Ivabradine and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ivabradine belongs to Cardiovascular; Lopinavir belongs to Anti Virals.
為什麼會發生
Ritonavir-boosted lopinavir inhibits CYP3A4, reducing ivabradine metabolism.
處置方式
Avoid use together and select an alternative therapy for heart rate control.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ivabradine 的其他交互作用
Lopinavir 的其他交互作用
常見問題
Can I take Ivabradine with Lopinavir?
MediHelp rates the interaction as contraindicated. Ivabradine and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is co-formulated with ritonavir, which strongly inhibits CYP3A4 and increases ivabradine levels. Excessive bradycardia and conduction disturbances may follow.
How serious is the interaction between Ivabradine and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use together and select an alternative therapy for heart rate control.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
