藥物交互作用
Levothyroxine + Sodium polystyrene sulfonate
嚴重程度: 中度
Levothyroxine and Sodium polystyrene sulfonate: moderate interaction.
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摘要
Sodium polystyrene sulfonate can bind oral levothyroxine in the gut and reduce its absorption. This may lower thyroid hormone exposure and lead to hypothyroidism over time.
用白話說明這項交互作用的意義
Levothyroxine and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Sodium polystyrene sulfonate belongs to Miscellaneous.
為什麼會發生
Binding of levothyroxine in the gastrointestinal tract by the resin reduces its absorption.
處置方式
Give levothyroxine at least 3 hours apart from sodium polystyrene sulfonate. Monitor TSH and adjust the levothyroxine dose if needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Levothyroxine 的其他交互作用
Sodium polystyrene sulfonate 的其他交互作用
常見問題
Can I take Levothyroxine with Sodium polystyrene sulfonate?
MediHelp rates the interaction as moderate. Levothyroxine and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate can bind oral levothyroxine in the gut and reduce its absorption. This may lower thyroid hormone exposure and lead to hypothyroidism over time.
How serious is the interaction between Levothyroxine and Sodium polystyrene sulfonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levothyroxine at least 3 hours apart from sodium polystyrene sulfonate. Monitor TSH and adjust the levothyroxine dose if needed.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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