藥物交互作用
Calcium carbonate + Sodium polystyrene sulfonate
嚴重程度: 中度
Calcium carbonate and Sodium polystyrene sulfonate: moderate interaction.
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摘要
Sodium polystyrene sulfonate can bind calcium in the gut, and the antacid effect of calcium carbonate may be offset by cation exchange. Reduced binding of bicarbonate-producing cations has been associated with metabolic alkalosis, especially in renal impairment. Clinical impact is usually modest but can matter in dialysis patients.
用白話說明這項交互作用的意義
Calcium carbonate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Sodium polystyrene sulfonate belongs to Miscellaneous.
為什麼會發生
Non-absorbed cation-exchange resin binds calcium and other cations in the gut, and combined with non-absorbable antacid it can leave bicarbonate unneutralized and cause systemic alkalosis.
處置方式
Separate administration by at least 3 hours (6 hours in gastroparesis) and monitor serum calcium, potassium and acid-base status in renal impairment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Calcium carbonate 的其他交互作用
Sodium polystyrene sulfonate 的其他交互作用
常見問題
Can I take Calcium carbonate with Sodium polystyrene sulfonate?
MediHelp rates the interaction as moderate. Calcium carbonate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate can bind calcium in the gut, and the antacid effect of calcium carbonate may be offset by cation exchange. Reduced binding of bicarbonate-producing cations has been associated with metabolic alkalosis, especially in renal impairment. Clinical impact is usually modest but can matter in dialysis patients.
How serious is the interaction between Calcium carbonate and Sodium polystyrene sulfonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 3 hours (6 hours in gastroparesis) and monitor serum calcium, potassium and acid-base status in renal impairment.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
