藥物交互作用
Micafungin + Sirolimus
嚴重程度: 中度
Micafungin and Sirolimus: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Micafungin modestly increases sirolimus exposure in healthy volunteer data. Higher sirolimus levels may increase the risk of hyperlipidemia, cytopenias, impaired wound healing and mucositis.
用白話說明這項交互作用的意義
Micafungin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Micafungin belongs to Anti Fungals; Sirolimus belongs to Miscellaneous.
為什麼會發生
Probable weak inhibition of CYP3A4-mediated sirolimus metabolism; the mechanism is not fully established.
處置方式
Monitor sirolimus trough concentrations when micafungin is started or stopped. Adjust the sirolimus dose according to levels and signs of toxicity.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Micafungin 的其他交互作用
Sirolimus 的其他交互作用
常見問題
Can I take Micafungin with Sirolimus?
MediHelp rates the interaction as moderate. Micafungin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Micafungin modestly increases sirolimus exposure in healthy volunteer data. Higher sirolimus levels may increase the risk of hyperlipidemia, cytopenias, impaired wound healing and mucositis.
How serious is the interaction between Micafungin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when micafungin is started or stopped. Adjust the sirolimus dose according to levels and signs of toxicity.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Avapritinib. The full list is on the Micafungin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
