藥物交互作用
Mitoxantrone + Oteseconazole
嚴重程度: 中度
Mitoxantrone and Oteseconazole: moderate interaction.
最後更新
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摘要
Oteseconazole inhibits BCRP, a transporter involved in mitoxantrone efflux and elimination. Exposure to mitoxantrone may rise, increasing the risk of bone marrow suppression and cardiotoxicity. Oteseconazole has a very long half-life, so the effect may persist.
用白話說明這項交互作用的意義
Mitoxantrone and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Oteseconazole belongs to Anti Fungals.
為什麼會發生
Oteseconazole inhibits BCRP, reducing efflux and clearance of mitoxantrone.
處置方式
Monitor complete blood counts and cardiac status closely. Consider using the lowest effective mitoxantrone dose, or choose an alternative if feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Mitoxantrone 的其他交互作用
Oteseconazole 的其他交互作用
常見問題
Can I take Mitoxantrone with Oteseconazole?
MediHelp rates the interaction as moderate. Mitoxantrone and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP, a transporter involved in mitoxantrone efflux and elimination. Exposure to mitoxantrone may rise, increasing the risk of bone marrow suppression and cardiotoxicity. Oteseconazole has a very long half-life, so the effect may persist.
How serious is the interaction between Mitoxantrone and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and cardiac status closely. Consider using the lowest effective mitoxantrone dose, or choose an alternative if feasible.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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