Drug interactions
Ambrisentan + Posaconazole
Severity: Minor
Ambrisentan and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may modestly raise ambrisentan concentrations because ambrisentan is partly cleared by CYP3A4. The clinical effect is generally small and ambrisentan labeling does not require a dose change with strong CYP3A inhibitors.
What this interaction means in plain words
Ambrisentan and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 (and possibly P-gp) reduces the partial oxidative clearance of ambrisentan.
What to do
No dose adjustment is usually needed; watch for ambrisentan adverse effects such as peripheral edema, headache and anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Posaconazole?
MediHelp rates the interaction as minor. Ambrisentan and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may modestly raise ambrisentan concentrations because ambrisentan is partly cleared by CYP3A4. The clinical effect is generally small and ambrisentan labeling does not require a dose change with strong CYP3A inhibitors.
How serious is the interaction between Ambrisentan and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for ambrisentan adverse effects such as peripheral edema, headache and anemia.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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