Drug interactions
Aminolevulinic acid + Piroxicam
Severity: Moderate
Aminolevulinic acid and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminolevulinic acid increases protoporphyrin-related photosensitivity, and additional phototoxic drugs may increase skin reactions. Piroxicam is a recognized photosensitizing NSAID, so the additive risk is more plausible. The concern is limited to the perioperative period.
What this interaction means in plain words
Aminolevulinic acid and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive phototoxic potential from drugs that sensitize the skin to light.
What to do
Avoid giving piroxicam for 24 hours after oral aminolevulinic acid where an alternative analgesic is available. Counsel the patient to protect skin and eyes from light exposure during that time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aminolevulinic acid and Piroxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Piroxicam?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid increases protoporphyrin-related photosensitivity, and additional phototoxic drugs may increase skin reactions. Piroxicam is a recognized photosensitizing NSAID, so the additive risk is more plausible. The concern is limited to the perioperative period.
How serious is the interaction between Aminolevulinic acid and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving piroxicam for 24 hours after oral aminolevulinic acid where an alternative analgesic is available. Counsel the patient to protect skin and eyes from light exposure during that time.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
