Drug interactions
Amiodarone + Silodosin
Severity: Moderate
Amiodarone and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein, which silodosin is a substrate of, so silodosin exposure may rise. This could increase adverse effects such as orthostatic hypotension and dizziness.
What this interaction means in plain words
Amiodarone and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Inhibition of P-glycoprotein efflux by amiodarone increases silodosin absorption and reduces its clearance.
What to do
Monitor for orthostatic hypotension and dizziness, especially after starting or increasing amiodarone. Reduce or reassess silodosin if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Silodosin?
MediHelp rates the interaction as moderate. Amiodarone and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein, which silodosin is a substrate of, so silodosin exposure may rise. This could increase adverse effects such as orthostatic hypotension and dizziness.
How serious is the interaction between Amiodarone and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, especially after starting or increasing amiodarone. Reduce or reassess silodosin if symptoms occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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