Drug interactions
Amisulpride + Avapritinib
Severity: Moderate
Amisulpride and Avapritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and amisulpride also causes sedation. Taken together they may increase drowsiness and impair concentration.
What this interaction means in plain words
Amisulpride and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Avapritinib belongs to Oncology.
Why it happens
Additive CNS effects; no pharmacokinetic mechanism is established.
What to do
Monitor for sedation and cognitive changes, and advise against driving if affected. Reduce or withhold doses according to the avapritinib label if CNS effects become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Amisulpride with Avapritinib?
MediHelp rates the interaction as moderate. Amisulpride and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and amisulpride also causes sedation. Taken together they may increase drowsiness and impair concentration.
How serious is the interaction between Amisulpride and Avapritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and advise against driving if affected. Reduce or withhold doses according to the avapritinib label if CNS effects become significant.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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