Drug interactions
Amisulpride + Flibanserin
Severity: Moderate
Amisulpride and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and CNS depression. Combined use may increase sedation, dizziness, hypotension and syncope, and impair psychomotor performance.
What this interaction means in plain words
Amisulpride and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel the patient about additive drowsiness and avoiding driving or hazardous tasks. Monitor for excessive sedation and hypotension, and reduce the amisulpride dose or stop flibanserin if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Flibanserin?
MediHelp rates the interaction as moderate. Amisulpride and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and CNS depression. Combined use may increase sedation, dizziness, hypotension and syncope, and impair psychomotor performance.
How serious is the interaction between Amisulpride and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and avoiding driving or hazardous tasks. Monitor for excessive sedation and hypotension, and reduce the amisulpride dose or stop flibanserin if needed.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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