Drug interactions
Amisulpride + Itraconazole
Severity: Moderate
Amisulpride and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride causes dose-related QT prolongation, and itraconazole has been associated with QT effects, mainly through interactions with other drugs. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Monitor ECG and correct hypokalemia and hypomagnesemia during combined use. Avoid in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Itraconazole?
MediHelp rates the interaction as moderate. Amisulpride and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride causes dose-related QT prolongation, and itraconazole has been associated with QT effects, mainly through interactions with other drugs. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct hypokalemia and hypomagnesemia during combined use. Avoid in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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