Drug interactions
Amisulpride + Meperidine
Severity: Moderate
Amisulpride and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride can cause sedation, and combined use with an opioid may add to CNS depression, hypotension and impaired alertness. Meperidine can also lower the seizure threshold, and amisulpride has QT effects that can matter in vulnerable patients.
What this interaction means in plain words
Amisulpride and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects from dopamine antagonism and opioid receptor agonism.
What to do
Monitor for oversedation and hypotension, and start with lower opioid doses. Check the ECG if the patient has additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Meperidine?
MediHelp rates the interaction as moderate. Amisulpride and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride can cause sedation, and combined use with an opioid may add to CNS depression, hypotension and impaired alertness. Meperidine can also lower the seizure threshold, and amisulpride has QT effects that can matter in vulnerable patients.
How serious is the interaction between Amisulpride and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension, and start with lower opioid doses. Check the ECG if the patient has additional QT risk factors.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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