Drug interactions
Amisulpride + Temazepam
Severity: Moderate
Amisulpride and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is an intermediate-acting benzodiazepine hypnotic. With amisulpride, sedation, dizziness and impaired psychomotor performance can be additive, raising the risk of falls and accidents.
What this interaction means in plain words
Amisulpride and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and amisulpride's sedative effects.
What to do
Use the lowest effective temazepam dose for the shortest duration and monitor for excess sedation, especially in older adults. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Amisulpride with Temazepam?
MediHelp rates the interaction as moderate. Amisulpride and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is an intermediate-acting benzodiazepine hypnotic. With amisulpride, sedation, dizziness and impaired psychomotor performance can be additive, raising the risk of falls and accidents.
How serious is the interaction between Amisulpride and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose for the shortest duration and monitor for excess sedation, especially in older adults. Advise avoiding alcohol and driving.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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